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Healthy cells have a GSH/GSSG ratio above 100 at rest, while cells exposed to oxidative stress have a ratio between 1 and 10

C14:1/C14 = VLCAD deoiciency

Potential Benefits in Diabetes: It may help prevent kidney damage associated with diabetes, as glutathione levels are frequently low in diabetic individuals

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Knockdown of METTL14 by siRNA significantly reduces GPX4 mRNA m^6A modification, restores GPX4 expression, alleviates ECM degradation, and ultimately inhibits chondrocyte ferroptosis in vitro (176)

Studies in animals have shown promising results for insulin delivery using this technique