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Two structural modifications distinguish this analog from the parent tridecapeptide: substitution of Met-4 with norleucine (Nle) and inversion of Phe-7 to the D-enantiomer, both of which are widely documented in the peptide chemistry literature as means of increasing conformational and oxidative stability of the reference standard

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In patients with T2DM, treatment with SGLT2is reduced infiltration of inflammatory cells into arterial plaques 107 and decreased the mRNA expression levels of some cytokines and chemokines, such as TNF, IL-6 and monocyte chemoattractant protein 1 (MCP1) 108

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