The animal handling and care methods were strictly approved by the NIH principles and the guidelines of the Institutional Animal Care and Use Committee (IACUC) (protocol approval code: AU 04,210,224,303), Alexandria University, Egypt
The dose stays consistent while the frequency decreases, followed by 48 weeks off
These medications typically come in pre-filled, single-dose auto-injector pens
INTRODUCTION Methotrexate (MTX) is a synthetic antimetabolite with many therapeutic indications, mainly anti-inflammatory and immunosuppressant at relatively low doses and antineoplastic at high doses.[ , ] MTX competitively inhibits dihydrofolate reductase, so decreasing tetrahydrofolate level leads to blocks the synthesis of purines, pyrimidines, DNA, ribonucleic acid, thymidylate, and proteins.[ , , ] It is well known that MTX is a hepatotoxic drug, and this leads to limitation of its clinical use
Regulatory agencies increasingly recognize the value of surrogate endpoints, adaptive trial designs, and biomarker-driven patient stratification, particularly in areas of high unmet need
Western medicine is interesting
