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Glucocorticoid-Related Signaling and Side-Effect Models Glucocorticoids, while clinically valuable in many inflammatory and immune-mediated conditions, can induce catabolic side effects: Catabolism and Tissue Integrity: Prolonged glucocorticoid exposure is associated with muscle wasting, increased fat accumulation, and reductions in bone density in experimental systems

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This study describes the reverse flux of glutamine through IDH to citrate in a HIF-dependent manner

However, no large-scale human clinical trials have confirmed these effects, so its use in people remains experimental and off-label