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During the blinded data review an indication of period effect was noted and properly registered as follow up action according to the Statistical Analysis Plan of the trial protocol

In participants given the highest dose (4.5 mg) of the once-weekly dulaglutide, the mean weight loss was about ten pounds at 36 weeks, with continued weight loss at the 52-week mark

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Collectively, these studies implicate a rationale to use DPP4 inhibitors for vascular repair through stimulation of EPC and neovascularization

Vomiting & Diarrhea: Common as the body adjusts to the medication