is glutathione a major antioxidant Metabolism - an overview Natural Compounds and Glutathione: Beyond

Toxicol Res Appl 4:4751 Hemachand T, Shaha C (2003) Functional role of sperm surface glutathione S-transferases and extracellular glutathione in the haploid spermatozoa under oxidative stress

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A fragment of the hypophosphatemic factor, MEPE, requires inducible cyclooxygenase-2 to exert potent anabolic effects on normal human marrow osteoblast precursors

Normal fibroblasts turn into cancer-associated fibroblasts (CAFs), followed by the creation of neoplastic transformation of epithelia

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Among them, the glutamate produced by the decomposition of glutamine via GLS not only provides the raw material for the synthesis of GSH but is also further metabolized into -ketoglutarate (-KG) in the mitochondria under the action of glutamate dehydrogenase (GLUD1) or transaminases and then enters the tricarboxylic acid cycle to produce ATP [29]