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A: Overuse can lead to irritation, redness, dryness, sensitivity, and in rare cases a condition linked to prolonged use called ochronosis

This observation aligns with findings from Drucker et al., who noted that GLP-1 receptor agonist-associated pancreatitis often occurs in the absence of classical risk factors, suggesting that the drug itself may induce pancreatic inflammation independent of other etiologies [15]

for missing data due to other intercurrent events, these were imputed based on retrieved dropouts in the same treatment arm, defined as observed primary outcome measurements, from participants in the same treatment group, who had their efficacy assessed after early discontinuation of the study drug

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Sattar et al., 2021)