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The FIGHT study showed that more vulnerable HF patients with severely reduced HRQoL and perhaps more advanced stages of the disease may require complex care planning to improve their health status rather than solely increasing glucose and fatty acid metabolism to enhance cardiac metabolism

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This multi-receptor mechanism distinguishes it from existing approved therapies such as semaglutide or tirzepatide, and it is this broad pharmacological activity that underpins both its therapeutic potential and its side effect profile

Strengthening this system through lifestyle, precursor supplementation, and, where appropriate, modern delivery methods may not cure diabetes, but it offers a way to slow its progression, protect vulnerable organs, and reshape metabolic health for the long run