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However, more participants discontinued treatment with tirzepatide 10 mg (OR 2.39 [95% CI 1.02, 5.59], I 2 0%) and 15 mg (OR 3.64 [95% CI 1.51, 8.78], I 2 13%) when compared with placebo (ESM Table 3)

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2.2 Rat studies Studies with laboratory rats were conducted in accordance with the standards of the Federal Republic of Germany (similar to AAALAC equivalents) under license numbers SYN01/16, SYN07/20, and SYN01/22, provided by the Regierungsprsidium Tbingen ethics committee