In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years
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Benefits of B12 Vitamin B12 does a lot of important things for your body
B12 shots are used to treat diabetes, Alzheimers disease, asthma, allergies, osteoporosis, and other chronic health conditions
Neurological function: Vitamin B12 is essential for maintaining healthy nerve cells and the production of myelin, a fatty substance that protects nerve fibers
On the other hand, injectable vitamins go directly into the bloodstream, providing nearly 100% absorption