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Pairing them in one pen exploits non-overlapping desensitisation pathways: GHRH-R signals through Gs/cAMP while GHS-R1a couples Gq/PLC, so receptor downregulation on one axis does not blunt the other during repeat-dose research models

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Kunimatsu J, Suzuki TW, Ohmae S, Tanaka M

It is important to understand the factors that affect BAC and how the effects of drinking alcohol vary among individuals