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As noted above, astrocyte reactivity is associated with diverse changes in molecular expression that can vary from mild to pronounced and that are highly context dependent

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found that NAM attenuated fibrosis by downregulating DNL genes, TGF-, and -SMA (Loza-Medrano et al

In turn, this coordinated engagement of death programstogether with precedent from oncologysupports the view that Erastin has therapeutic potential for EMS when exposure is directed preferentially to lesions and minimized in normal tissues