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However, in a world of plenty, this advantage would turn into a disadvantage and give fast increases in body weight, hyperinsulinemia, and the development of metabolic syndrome problems early on (reviewed by Dunger et al (48)

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The application of melanotan 2 in this context may have implications for the treatment of obesity, especially in MC4R-deficient subjects who are prone to the disease [12, 13, 14]

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