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However, DPP-4 inhibitors have not reduced the risk of major adverse cardiovascular events, possibly because potentiation of SDF-1 enhances plaque growth and instability, activates deleterious neurohormonal mechanisms, and promotes cardiac inflammation and fibrosis

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Selective DNAzyme-mediated cleavage of achr mutant transcripts by targeting the mutation site or through mismatches in the binding arm

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