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Harada et al., 2021

Etiology Glutathione synthetase catalyses the last step in the synthesis of glutathione and a deficiency results in low levels of glutathione (Figure 1)

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We previously showed that an acute one-week MOTS-c treatment reversed age-dependent insulin resistance in mouse skeletal muscle 15

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A subsequent analysis suggested that NAC may benefit a subgroup of IPF patients with the TOLLIP rs3750920 TT genotype (Oldham et al., Am J Respir Crit Care Med, 2015) [46]