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Common symptoms include heavy menstrual bleeding (menorrhagia), iron deficiency anemia from blood loss, pelvic pressure or pain, abdominal distension, bladder frequency or incomplete emptying (anterior fibroids), constipation or rectal pressure (posterior fibroids), menstrual clotting, and, in some cases, recurrent pregnancy loss or difficulty conceiving

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through these entry sites, multiple pathways are engaged in providing input to key appetite-modulating relay stations, such as the parabrachial nucleus (PB)