doi: 10.1016/j.neuropharm.2022.108963, 64
Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response
It binds GHS-R1a with high affinity but shows minimal activity at other receptor systems, including those mediating cortisol release (CRH/ACTH axis), prolactin release, or appetite stimulation pathways independent of GH signaling
Tutwiler V, Mukhitov AR, Peshkova AD, Le Minh G, Khismatullin RR, Vicksman J, et al
That is why it is somewhat paradoxical to view it as anaid to weight loss
These behavioral benefits are underpinned by its marked ability to induce spinogenesis and promote functional synaptogenesis in hippocampal neurons, highlighting its potential as a robust procognitive and antidementia agent [2]