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Moderate cardiovascular activity (walking, cycling, swimming) provides important benefits during Retatrutide treatment: Enhanced insulin sensitivity: Aerobic exercise improves glucose uptake and metabolic flexibility Cardiovascular conditioning: Maintains heart health and aerobic capacity during weight loss Mental health benefits: Regular movement reduces anxiety and improves mood, particularly important during medication adjustment phases Additional caloric deficit: Can modestly accelerate fat loss when combined with resistance training Active recovery: Light cardio between resistance sessions promotes blood flow and recovery The key is moderation

However, weight loss is not always linearsome weeks show greater drops while others plateau as the body adapts to the medication and lifestyle changes

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For more detail on nutrition alongside weight loss peptides, explore our guides on peptides for weight loss in women and fat-burning approaches for men

doi: 10.1038/nm.3016 67 KruegerJG