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J Nutr 2006, 136: 1660S-1665S

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doi: 10.1101/2024.11.07.24316777 286 BowerJEGanzPAAzizN

MTHFR polymorphism and psychiatric diseases Extensive clinical studies demonstrated a significant linkage between MTHFR polymorphism and various diseases, such as cardiovascular diseases, neuronal developmental diseases, cancers as well as psychiatric disorders

148,149 Proliferating cancer cells exhibit aerobic glycolysis, leading to a shift in glucose carbon away from the TCA cycle, which results in the increased use of glutamine to fuel anabolic processes to support rapid cell growth with increased NADPH and ammonia generation