semaglutide oral pill ACC 2025: Reduces Cardiovascular Events by 14% at 4 Years Oral Semaglutide for Weight Loss

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Both drugs use semaglutide, a GLP-1 RA, and are manufactured by Novo Nordisk

Safety Considerations and Side Effects of GLP-1 Agonists Whilst GLP-1 receptor agonists are generally well-tolerated, patients and prescribers must be aware of potential adverse effects and important safety considerations

Interestingly, a study that did implement this titration approach found during the maintenance phase, rats treated with semaglutide showed a unexpected marked increase in the intake of lower concentrations of sucrose compared to vehicle treated controls, despite continuing to consume chow at only 90% the level of vehicle-treated animals (Cawthon et al., 2023)