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Avoid semaglutide, Ozempic, or Wegovy if you or a family member has a history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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The 2,2-dimethyl substitution pattern on this ring occupies a lipophilic sub-pocket between TM2 and TM3 that is highly conserved in the GLP-1 receptor but differs in related class B GPCRs such as the glucagon and GIP receptors

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