108 LimC
I., & Cheresh, D
L.SinghR.SinghA.ChudasamaY.ColesB.et al (2020)
Lifestyle intervention Several major trials have shown some effective interventions to prevent the occurrence of T2D and even reduce the risk of TOD
Clinical overviews note that extra abdominal fat is strongly associated with smaller lung volumes and breathlessness, specifically because it inhibits diaphragm excursion
The key pathways including lipotoxicity and oxidative stress (involving NLRP3 inflammasome, MAPK, PI3K/Akt, and RAAS signaling), inflammation (via NF-B, NLRP3 inflammasome, JAK-STAT, Toll-like receptor, and cGAS-STING pathways), and fibrosis/ECM production (driven by TGF-, Wnt, RAAS, and Notch signaling) have been identified and reported in CKD progression [235]