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Available at: [Accessed 17 January 2024]

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These findings support the notion that, similar to the development of peripheral opioid receptor antagonists, developing therapeutic targeting specific brain regions is one of several avenues that warrant exploration for patients unresponsive to current therapies

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[38-40] Carotenoids and Vitamin A can absorb peroxyl radicals and singlet oxygen and regulate the expression of COX-2, NO, production, cell differentiation, bone metabolism, and vision