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For HSP70s, chaperone-mediated autophagy via SARs such as lysosome-associated membrane protein 2A (LAMP2A) is rather typical (Venediktov et al., 2023), although HSP70s may also engage additional machinery

Here's the responsible way to think about all of this: warning letters and lawsuits are not proof of wrongdoing

Warn the owner that a delay in diagnosing the problem and instituting appropriate therapy, if available, may result in irreversible muscle damage Discuss with the owner that some disorders are untreatable and that nothing tried may work

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