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And the newest entrant, retatrutide a triple agonist hitting GLP-1, GIP, and glucagon receptors achieved 28.7% body weight loss in its Phase 3 TRIUMPH-4 trial (published December 2025)

Poorly controlled diabetes, immunosuppression, antibiotic use, or other predisposing factors may need addressing

Common side effects include: Stomach Problems: NSAIDs can irritate the stomach lining, leading to heartburn, nausea, or more severe issues like ulcers or bleeding