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Rich in bioactive compounds, notably natural caffeine and polyphenols, it holds a historical place in local nutritional practices

High insulin levels reduce liver production of sex hormone-binding globulin (SHBG), increasing free circulating androgens

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Acknowledgments This research was supported by the UTMB Institute for Translational Sciences, supported in part by a Clinical and Translational Science Award (UL1 TR001439) from the National Center for Advancing Translational Sciences at the National Institutes of Health (NIH)

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While these changes are common, there are still ways to manage or address them