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Description IGF-1 LR3 (Long [Arg] Insulin-like Growth Factor-1) is a recombinant synthetic analog of human insulin-like growth factor 1, engineered with two structural modifications: an arginine substitution replacing glutamate at position 3 of the IGF-1 sequence (reducing IGFBP-3 binding affinity), and a 13-amino-acid N-terminal extension (Long peptide leader)

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824 Mechanistically, NAT10 promotes the ac4C RNA modification of NCOA4 mRNA, which increases its stability and ferritinophagy, promoting the ferroptosis of renal tubular epithelial cells induced by I/R injury

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