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doi: 10.4103/sjg.sjg_12_21 52 HetzCPapaFR

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Abe T, Sakaguchi Y, Ohno S, Ikeda Y, Kitamura K, Maehara Y, et al

Furthermore, APAP exposure significantly depletes glutathione [68], suggesting that repeated exposure to the drug is potentially more hazardous than a single exposure.Although APAP metabolism is well characterized, a high degree of variability in APAP metabolism within the pediatric population has been observed, and the factors affecting this variability are poorly understood [69]