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They work by reducing appetite, slowing how quickly the stomach empties, and improving the bodys response to insulin
The other authors declare no conflict of interest
Buse said that clinical trialswhich he and his team have been running on Ozempic and its predecessors since 1998had yet to demonstrate the same benefits as a healthy lifestyle, but added jocularly that "if you could hypnotize people and they changed their lifestyle forevermoretheir appetite was reduced
According to clinical trial data, Zepbound has shown a greater average weight loss for long-term results than Wegovy
Additionally, genetic variations in GLP-1 receptor genes, GIPR pathways, and metabolic genes (like FTO and MC4R) can influence individual responsiveness and risk tolerance
We also conducted a systematic review following the PRISMA guidelines, but we did not register it in the database
