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For example, the compound 13 (racemic) is a very week IRAP inhibitor ( 14 with a 4-hydroxydiphenylmethane scaffold as a substitute for Tyr 2 is essentially inactive (Figure 4) ( 1 is essential and the proper orientation of the Tyr 2 side chain in space is critical for activity and IRAP inhibition while various alternations and topography at the C-terminal are more acceptable

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doi:10.23736/S2784-8671.23.07594-1

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Researchers comparing the two should consult primary literature for each molecule rather than treating them as interchangeable