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Newer AOMs targeting the glucagon-like peptide 1 (GLP-1) receptor lead to weight loss by inducing a delay in gastric emptying and reducing food intake through central and peripheral satiety mechanisms [18]

Anti-rebound strategies should be integrated into the clinical pathway, including intensified lifestyle maintenance and, where appropriate, sequential metformin to maintain metabolic stability

Semaglutide may be more widely available due to its earlier approval, but demand has created global shortages for both drugs

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