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The Vida Health nurse said he was a good candidate for Zepbound but insisted he try two generic drugs first: naltrexone, a drug used to curb alcohol and opioid use, and bupropion, an antidepressant

Similarly, a 2023 study published in the Journal of the American Medical Association (JAMA) found that individuals taking GLP-1 drugs were more than four times as likely to experience bowel obstruction compared with patients using bupropion-naltrexone, another class of weight-management medication

doi: 10.1016/j.jemermed.2011.06.017

Further, miR-142-3p stimulates the ferroptosis in HBV-infected M1-type macrophages via SLC3A2, leading to the altered synthesis of GSH, malondialdehyde (MDA), and Fe2+ that potentially hastens the development of HCC (Hu et al., 2022)