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Consistent with its role in promoting lipid peroxidation, treatment with 0.5 M of ML162 significantly elevated BODIPY intensity, and increasing the dose of ML162 to 1 M further enhanced BODIPY intensity (Fig

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NF-B inhibition by the binding of taurochenodeoxycholic acid to TGR5 has also been shown to drastically reduce inflammatory phenotypes among astrocytes during experimental autoimmune encephalomyelitis [228]

While current treatments provide symptomatic relief, a disease-modifying therapy remains an unmet need