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Through metabolomic analysis of T2DM and DKD patients, they found that N-acetylaspartate, L-valine, betaine, isoleucine, asparagine, and L-methionine were significantly elevated in DKD patients, with high levels of L-leucine and isoleucine significantly associated with rapid estimated glomerular filtration rate (eGFR) decline

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A DNase I delivery system that mimics the inflammatory chemotactic effect of neutrophils has been shown to effectively prevent inflammatory damage to lung tissues in an LPS-induced acute lung injury mouse model (124), suggesting that targeting NETs to alleviate acute lung inflammation is also a feasible approach

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Comments Foci of cellular alteration represent a localized proliferation of hepatocytes that are phenotypically different from surrounding hepatocyte parenchyma