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Previous studies have demonstrated that gut-derived GLP-1 activates vagal sensory nerves, triggering insulin secretion via brain-autonomic nervous system pathways, a mechanism referred to as the "neuro-incretin effect" [51, 59]

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The FDAs Announcement On April 16, 2026, the FDA published a Federal Register notice announcing a formal advisory committee review tied to several peptide-related bulk drug substances

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Additionally, an increase in the pyruvate content was also observed (Figure 3D)