You can not be treated with semaglutide or Tirzepatide if you have: Medullary thyroid cancer Multiple endocrine neoplasia Type 1 diabetics Type 2 diabetics already taking a GLP-1 medication History of pancreatitis Chronic kidney disease (unless cleared by nephrologist) Nursing, pregnant, or trying to get pregnant Short moments of nausea, Constipation or diarrhea Fatigue Takes away desire for alcohol Yes, unlike vaccines or many other shots you may think of, this injection is done with a tiny needle that only goes under the skin, not into muscle
10.1159/000314690 55 FarngrenJ.PerssonM.SchweizerA.FoleyJ
Designing small molecules able to target multiple receptors might sound difficult, but Septerna says the allosteric binding site it has discovered is even better conserved across all incretin receptors than the site targeted by peptides and other small molecule drugs
Focus on tirzepatide, a dual unimolecular GIP-GLP-1 receptor agonist in type 2 diabetes
Use sparingly
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