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Furthermore, diabetes is known to disrupt bile secretion and metabolism, such as through impaired insulin-mediated bile signaling, leading to bile composition changes that increase gallstone risk (59)

In turn, the increased estrogen levels suppress the HPG axis and lower testosterone levels, which may cause erectile dysfunction, a chronic disorder [13]

A predefined drop-out level was estimated to be about 15%

Various abiotic stresses rapidly activate Arabidopsis MAP kinases AtMPK4 and AtMPK6