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10.3233/JPD-191702 J

Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial

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*Eligible patients with a BMI of 30, or 27 with comorbidities, lost an average of 19% of their body weight (-33.6 lbs) in a 68-week clinical trial evaluating 2.4 mg semaglutide, when combined with a reduced-calorie diet and increased physical activity

Factors such as chronotype, comorbidities, sex-specific differences, light exposure patterns, frailty status, and polypharmacy can significantly influence circadian responsiveness and metabolic outcomes