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In diet-induced obesity animal models, NNMT inhibition demonstrated metabolic changes including alterations in adipocyte lipid content without affecting food intake patterns, coupled with significant reductions in white adipose tissue mass in treated mice

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Reductions in levels of inflammatory marker C-reactive protein (0.34 versus 0.74, ratio to baseline) and in lipids (blood fats), including nonhigh density lipoprotein cholesterol (0.90 versus 0.96, ratio to baseline) and triglycerides (0.73 versus 0.87, ratio to baseline), were also observed