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Researchers who have struggled with tirzepatide losing effectiveness over time might consider whether switching to CagriSema when it becomes available could reignite weight loss through the different amylin-based mechanism

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doi: 10.1007/s11920-022-01369-6 36 MaNZhangJReiterRJMaX

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Future trials should adopt: Adaptive designs : allow protocol adjustments based on interim data

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Similarly, despite the reported tolerability and indication of efficacy of the MCHR1 antagonist ALB-127158, its development was terminated before the initiation of Phase II studies

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