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Where resources are scarce, you need to put them to the individuals most at risk, and its fair to say those individuals with diabetes which is poorly controlled who are deriving good benefit from this medication need to be prioritised over other indications, says Wright

Furthermore, developing small molecule inhibitors targeting BCAA transporters in tumor cells and immunosuppressive cells allows CD8 + T cells to obtain amino acid metabolic advantages in the immune microenvironment and enhance the anti-tumor effect

Patients with a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, uncontrolled diabetes, or severe renal impairment should not use GLP-1 medications

doi: 10.1111/j.1468-3083.2009.03524.x

In 2022, Saxenda generated 10.68 billion DKK ($1.51 billion USD) in sales

These additions do not undermine weight loss because even with them, most patients on GLP-1 therapy still maintain a significant caloric deficit