If appropriate, we create a structured dosing plan and provide ongoing monitoring
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In a follow-up study, the same group demonstrated that HPDL deficiency induces a lethal form of mitochondrial encephalopathy and, importantly, supplementation with HPDL-derived intermediates (4-HMA or 4-HB) was sufficient to alleviate disease symptoms
Pain-like behavior in the collagen antibody-induced arthritis model is regulated by lysophosphatidic acid and activation of satellite glia cells
Regulatory T-cells express high levels of CTLA-4, and therefore may be inactivated by ipilimumab and allow effector T cell activation, causing both tumour response and colitis
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