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The next step in the pathway is the conversion of 3-hydroxyanthranilic acid to quinolinic acid catalyzed by the enzyme 3-hydroxyanthranilate 3,4-dioxygenase which is encoded by the HAAO gene

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Since the drug is still very expensive, with a list price of more than $1,300 for a 28-day supply, Medicare could find itself on the hook for a hefty bill since a large percentage of the population could qualify for it