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Traditional GLP-1 weight loss drugs like Wegovy (semaglutide) or Mounjaro/Zepbound (tirzepatide) often result in muscle loss, which can adversely affect overall health outcomes

Expression of the mutant human B-crystallin in mice resulted in a cardiomyopathy, with progressive heart failure, and sudden, premature death

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This has prompted interest in advanced delivery methods, like nanoparticles and co-administration with piperine, to improve absorption

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There are also several prescription weight loss alternatives available, such as Saxenda, Orlistat and Mysimba