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Data from preclinical models in mice and human data also suggest that the tolerability and efficacy of GLP-1 agonists vary with the hormonal cycle and that higher circulating estrogen levels are associated with a heightened risk of nausea and vomiting

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For example, the North American Thrombosis Forum found that patients with inflammatory bowel disease (IBD) may have a 3-4 times higher risk of developing thrombosis (blood clots) than people without IBD. It is well-documented that Ozempic can cause significant gastrointestinal side effects, from diarrhea to gastroparesis

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