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Upon activation, these T cells release interferon- (IFN-), which downregulates neuronal expression of ferritin heavy chain (FTH1), resulting in increased intracellular labile iron, thereby enhancing susceptibility to ferroptosis

Together, these factors form a complex network linking CD8 + T cell function, ferroptosis, and cancer immunity ( Fig

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(2012) Identification of a new gene required for the biosynthesis of rhodoquinone in Rhodospirillum rubrum , J