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H 2 O 2 reduced mitochondrial membrane potential and increased ROS production in treated RA-FLS and activation of caspase-3, caspase-9, and Bax to induce FLS apoptosis, a process associated with oxidative stress-mediated activation of macrophage stimulating 1 (Mst1) and inhibition of the AMPK-Sirt1 signaling pathway (129)

Normally, glomeruli tiny blood vessels in your kidneys filter water and salts out of your blood while preventing larger particles like blood cells and proteins from passing through