The homogenate was centrifuged at 800 g for 10 min, followed by centrifugation of the supernatant at 8,000 g for 10 min
Results Electrophoresis analysis of peptide expression Figure 1 shows successful expression of DSIP-CBBBP, CBBBP, and DSIP
Meanwhile, the activities of glutathione reductase (GR) and superoxide dismutase (SOD) enzymes were also enhanced after APP treatment, while the catalase (CAT) activity decreased
More specifically, its a basic building block of glutathione, which has been coined the mother of all antioxidants. L-cysteine supplementation, also known as N-acetyl-L-cysteine (NAC), is valued for its ability to increase glutathione levels in the body, which is extremely important for lung function, brain function and liver detoxification
62 GSH Depletion and Antibiotic Susceptibility Intense antibiotic or host-induced stress can deplete bacterial GSH pools, tipping the balance toward cell death
This occurs through the impairment of thioredoxin 2 (Trx2) activity, which subsequently triggers the release of a cascade of proapoptotic factors, including the notable cyclophilin D, thereby influencing the apoptotic pathways and cellular homeostasis
