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the NR1H4 variants cause loss of BSEP expression, leading to the accumulation of toxic bile and hepatocellular damage, with rapidly progressive intralobular cholestasis in the neonatal period [1, 42, 48, 49]

For this page, the editorial team checks medical and regulatory claims against primary sources, clinical trials, public datasets, and regulator guidance

By serving as a Master Controller for signaling research, the 10mg concentration helps investigators decode the complex receptor dynamics across extended experimental timelines

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