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For these experiments, the controls consisted of untreated aVICs and treatment with TGF- 1 (5 ng/mL), a known stimulus of myofibroblastic differentiation 39

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Coumarin , L-leucine , and 3-indolepropionic acid emerged as top-ranking features based on mean decrease in accuracy, indicating their relative importance as diet-responsive metabolites within this cohort

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The effect on melanin production and skin tone is cumulative

The Japanese diet, characterized by a higher mushroom consumption, particularly Shiitake and Enokitake varieties, stands out